IL-4-inhibitor-1 - CAS 1332184-63-0

IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM) . It is selective for IL-4 over IL-13 (EC50= 18.2 μM) . IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50= 3.1 μM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway.

Interleukin, IL Receptor

Immunology/Inflammation

1332121

>99.99%

C18H12FN3O2

321.31

Nc1nc(cc(-c2ccc(O)c(O)c2)c1C#N)-c1ccc(F)cc1

-20°C

Ice Packs

Small Compound