IL-6-IN-2 - CAS 296790-70-0

IL-6-IN-2 (Compound 15) is an inhibitor of the interaction between IL-6 and IL-6R proteins. The compound's binding free energy (∆G) is −36.50 kcal/mol. In its binding with IL-6, the contributions from Lys66, Phe74, Gln175, Ser176, and Arg179 are -1.10, -8.68, -6.91, -3.69, and -1.72 kcal/mol, respectively. IL-6-IN-2 exhibits low gastrointestinal (GI) absorption rates.

Interleukin

Immunology/Inflammation

296720

C26H24N4O3

440.49

OC1=C(C(=NN1C=2C=CC=CC2)C)C(C=3OC(=CC3)C)C4=C(O)N(N=C4C)C=5C=CC=CC5

-20°C

Ice Packs

Small Compound