Ilorasertib - CAS 1227939-82-3

Ilorasertib (ABT-348) (ABT-348) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora A/Aurora B/Aurora C (IC50s: 120 nM/7 nM/1 nM) . It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM) .

Aurora Kinase, c-RET, VEGFR, FLT, PDGFR

Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, Angiogenesis, Cell Cycle/Checkpoint, Apoptosis

1227854

0.9803

C25H21FN6O2S

488.54

NC1=C2C(=C(C=N1)C3=CN(CCO)N=C3)SC=C2C4=CC=C(NC(NC5=CC(F)=CC=C5)=O)C=C4

-20°C

Ice Packs

Small Compound