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Ilorasertib hydrochloride - CAS 1847485-91-9

Ilorasertib hydrochloride - CAS 1847485-91-9

MF-0022601

$45.88 USD
$45.88 USD
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Product Details

  • Bioactivity

    Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM) . It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM) .

  • Target

    PDGFR, VEGFR, Aurora Kinase

  • Related Pathways

    Cell Cycle/Checkpoint, Tyrosine Kinase/Adaptors, Angiogenesis, Chromatin/Epigenetic

  • CAS Number

    1847385

  • Purity

    0.9845

  • Molecular Formula

    C25H22ClFN6O2S

  • Molecular Weight

    525

  • SMILES

    Cl.Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound