IMM-01 - CAS 218795-74-5

IMM-01 is a novel class of small-molecule agonists of the mammalian Diaphanous (mDia) -related formins, which act downstream of Rho GTPases to assemble actin filaments, and their organization with microfilaments to establish and maintain cell polarity during migration and asymmetric division. GTP-bound Rho activates mDia family members by disrupting the interaction between the DID and DAD autoregulatory domains, which releases the FH2 domain to modulate actin and microtubule dynamics[1].

Apoptosis, Ras, GTPase

GPCR/G Protein, Apoptosis, MAPK

218795-74-5

0.9887

C12H17N3O2S

267.35

CC(C)(C)NC(=S)N\N=C\C1=C(O)C=C(O)C=C1

-20°C

Ice Packs

Small Compound