Imofinostat - CAS 1338320-94-7

Imofinostat (MPT0E028) is a selective, orally available pan-HDAC inhibitor with IC50 values of 53.0/106.2/29.5 nM against HDAC1/HDAC2/HDAC6 in HCT116 cells. In B-cell lymphoma, Imofinostat induces cell cycle arrest and apoptosis whilst inhibiting Akt phosphorylation, demonstrating anticancer activity across multiple tumour types.

Apoptosis, Cell Cycle Arrest, Akt, HDAC

Chromatin/Epigenetic, Cytoskeletal Signaling, DNA Damage/DNA Repair, Cell Cycle/Checkpoint, PI3K/Akt/mTOR signaling, Apoptosis

1338219

C17H16N2O4S

344.38

ONC(=O)\C=C\c1ccc2N(CCc2c1)S(=O)(=O)c1ccccc1

-20°C

Ice Packs

Small Compound