INCB126503 - CAS 2640089-88-7

INCB126503 is an orally active and selective inhibitor of FGFR2/3, with IC50 values of 70 nM for FGFR1, 2.1 nM for FGFR2, 1.2 nM for FGFR3, 0.92 nM for FGFR3-V555L, 0.85 nM for FGFR3-V555M, and 64 nM for FGFR4. This compound inhibits FGFR signaling in vivo without causing hyperphosphatemia and demonstrates antitumor efficacy in xenograft models with FGFR3 genetic alterations.

FGFR

Angiogenesis, Tyrosine Kinase/Adaptors

2639994

C27H30N6O2

470.57

O(C)C=1C=C2C(C(=NN2)C=3C=CC(=NC3)N4C[C@]5(N(CC4)C[C@H](O)C5)[H])=NC1C6=C(C)C(C)=CC=C6

-20°C

Ice Packs

Small Compound