Indibulin - CAS 204205-90-3

Indibulin (D 24851) is a synthetic small molecule with antimitotic and potential antineoplastic activities.Indibulin an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis.

Microtubule Associated, Apoptosis, Chk

Apoptosis, Cell Cycle/Checkpoint, Cytoskeletal Signaling

204112

0.9983

C22H16ClN3O2

389.83

Clc1ccc(Cn2cc(C(=O)C(=O)Nc3ccncc3)c3ccccc23)cc1

-20°C

Ice Packs

Small Compound