Indomethacin - CAS 53-86-1

Indomethacin is an orally active nonsteroidal anti-inflammatory drug (NSAID) that non-selectively inhibits cyclooxygenase enzymes COX-1 and COX-2, with IC50 values of 18 nM and 26 nM, respectively. It exhibits good blood-brain barrier permeability and shows significant anti-inflammatory, anti-tumor, and anti-infective activities. Indomethacin is widely used in research related to cancer, inflammation, and viral infections, and is also commonly used to induce gastric ulcer models in animals.

PDE, Autophagy, COX, Phospholipase

Immunology/Inflammation, Metabolism, Autophagy, Neuroscience

53-86-1

0.9984

C19H16ClNO4

357.79

COC1=CC2=C(C=C1)N(C(=O)C1=CC=C(Cl)C=C1)C(C)=C2CC(O)=O

-20°C

Ice Packs

Small Compound