INE963 - CAS 2640567-43-5

INE963 demonstrates potent cellular activity against Pf 3D7 (EC50 = 6 nM) and achieves "artemisinin-like" kill kinetics in vitro with a parasite clearance time of <24 h. INE963 is also potent against P. falciparum and P. vivax clinical isolates from Brazil and Uganda with EC50's ranging from 0.01 to 7.0 nM

Haspin Kinase, Parasite, FLT, Others

Tyrosine Kinase/Adaptors, Others, Angiogenesis, Cell Cycle/Checkpoint, Microbiology/Virology

2640519

0.9945

C19H26N6O2S

402.51

COc1nc(ccc1-c1cnc2sc(nn12)N1CCC(O)(CN)CC1)C(C)C

-20°C

Ice Packs

Small Compound