Inflachromene - CAS 908568-01-4

Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene reduces seizure severity in a mouse model of epilepsy by inhibiting HMGB1 translocation, inhibits endothelial proliferation through the HMGB1/2-regulated TLR4-NF-κB pathway, and inhibits autophagy by regulating Beclin 1 activity. Inflachromene can be used to study epilepsy.

P38 MAPK, NF-κB, ERK, JNK, Others

MAPK, NF-κB, Others

908568-01-4

0.9988

C21H19N3O4

377.39

CC1(C)Oc2cc(O)ccc2C2C1=CCn1n2c(=O)n(-c2ccccc2)c1=O

-20°C

Ice Packs

Small Compound