INI-4001 - CAS 2549050-07-7

INI-4001, a TLR7/8 agonist, exhibits EC50 values of 1.89 μM and 4.86 μM for TLR7 and TLR8, respectively. This compound induces signal transduction and SEAP production through TLR7 and TLR8. Furthermore, INI-4001 stimulates the production of high-affinity, fentanyl-specific antibodies, effectively preventing fentanyl from crossing the human blood-brain barrier. It serves as an effective adjuvant in anti-fentanyl vaccines for individuals with opioid use disorder (OUD) .

TLR

Immunology/Inflammation

2549050-07-7

C59H109N6O13P

1141.5

C(N1C=2C(NC1=O)=C(N)N=C(O[C@H](CCC)C)N2)C3CCN(CCOP(OCCOCCOCCOC[C@H](OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)(=O)O)CC3

-20°C

Ice Packs

Small Compound