INNO-220 - CAS 3032576-92-1

INNO-220 is an orally active, CRBN-dependent molecular glue degrader that targets CK1α. By degrading CK1α, INNO-220 induces cell cycle arrest at the G0/G1 phase and triggers apoptosis (Apoptosis) . It disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, inhibiting the NF-κB signaling pathway in T cells and lymphoma cells with activating mutations in CARD11. INNO-220 offers a novel direction for lymphoma research.

Casein Kinase, Molecular Glues, MALT, MDM-2/p53

Immunology/Inflammation, Metabolism, PROTAC, Stem Cells, Apoptosis

3032483

C23H20N4O3

400.43

O=C1NC(=O)C(N2C(=O)C3=CC=C(C=C3C2)C=4C=NN(C4C=5C=CC=CC5)C)CC1

-20°C

Ice Packs

PROTAC