INU-152 - CAS 1380228-30-7

INU-152 is a pan-RAF inhibitor. INU-152 has potent anti-tumor activity in preclinical models of BRAFV600E mutant cancer. INU-152 inhibits all RAF isoforms and inhibits MAPK pathways in mutant BRAF cells. INU-152 exhibits minimal paradoxical pathway activation in melanoma cells with mutant RAS.

Autophagy, Raf, Apoptosis, Others

MAPK, Apoptosis, Others, Autophagy

1380191

C20H13F2N7O3S

469.42

N(C1=C(C2=C3C(=NC=N2)N=CN3)C=CC=N1)C4=C(F)C(NS(=O)(=O)C=5C=COC5)=CC=C4F

-20°C

Ice Packs

Small Compound