Ipatasertib-NH2 - CAS 1001382-14-4

Ipatasertib-NH2 (GDC-0068-NH2; RG7440-NH2) is a ligand for the target protein AKT used in PROTAC, binding to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 for AKT degradation[1].

Ligands for Target Protein for PROTAC, Others

PROTAC, Others

1001364

C21H26ClN5O2

415.92

C[C@H]1C2=C(N=CN=C2[C@H](O)C1)N3CCN(C([C@H](CN)C4=CC=C(Cl)C=C4)=O)CC3

-20°C

Ice Packs

PROTAC