Ipomoeassin F - CAS 915392-44-8

Ipomoeassin F, a selective and potent inhibitor of endoplasmic reticulum (ER) protein translocation, targets the Sec61 complex's pore-forming subunit (Sec61α) at the ER membrane. It inhibits the ER membrane translocation of SARS-CoV-2 proteins and blocks the ER translocation of secretory and type I transmembrane proteins (TMPs), without affecting type III TMPs [1] [2] [3].

Others, SARS-CoV

Others, Microbiology/Virology

915340

C44H62O15

830.95

O(C(/C=C/C1=CC=CC=C1)=O)[C@H]2[C@H](OC(/C(=C/C)/C)=O)[C@@H](O)[C@]3(O[C@@]2(COC(=O)CCC(=O)CCCCCC[C@H](CCCCC)O[C@]4([C@](O3)([C@@H](O)[C@@H](OC(C)=O)[C@@H](C)O4)[H])[H])[H])[H]

-20°C

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Natural Product