IRAK1/4/pan-FLT3 Kinase-IN-1 - CAS 2760328-82-1

IRAK1/4/pan-FLT3 Kinase-IN-1 (Compound 31) is a potent inhibitor of IRAK1, IRAK4, and FLT3 kinases, demonstrating IC50 values of 5 nM for IRAK1, 0.6 nM for IRAK4, and less than 0.5 nM for FLT3. It exhibits favorable pharmacokinetic properties and holds promise for research in acute myeloid leukemia, with survival extension effects comparable to Gilteritinib.

FLT, IRAK

Immunology/Inflammation, Tyrosine Kinase/Adaptors, NF-κB, Angiogenesis

2760245

C21H26FN5O2

399.46

C(C)(C)(O)C1=CN2C(=CN=C2C=C1OC)C=3N=C(N[C@@H]4[C@@H](F)CCNC4)C=CC3

-20°C

Ice Packs

Small Compound