IRAK1/4/pan-FLT3 Kinase-IN-2 - CAS 2760329-44-8

IRAK1/4/pan-FLT3 Kinase-IN-2 (compound 27) is a potent dual inhibitor of IRAK1/4 and FLT3 with IC50 values of 10 nM, 0.7 nM, and < 0.5 nM, respectively. This compound enhances survival in mice models of acute myeloid leukemia.

IRAK

Immunology/Inflammation, NF-κB

2760277

C20H22F3N5O

405.42

FC1=C(C=2N3C(C=C(OC(C)C)C=C3)=NC2)N=C(N[C@@H]4[C@@H](F)CCNC4)C(F)=C1

-20°C

Ice Packs

Small Compound