Irdabisant - CAS 1005402-19-6

Irdabisant (CEP-26401) (CEP-26401) is a selective, orally active and blood-brain barrier (BBB) penetrant antagonist/inverse agonist of histamine H3 receptor (H3R) (rat H3R Ki= 7.2 nM, human H3R Ki= 2.0 nM) . Irdabisant exhibits relatively low inhibitory activity against hERG current (IC50= 13.8 μM) . Irdabisant exhibits cognition-enhancing and wake-promoting activities in the rat social recognition model. Irdabisant can be used for research on schizophrenia or cognitive impairment.

Histamine Receptor

Immunology/Inflammation, Neuroscience, GPCR/G Protein

1005377

0.9996

C18H23N3O2

313.39

O(CCCN1[C@H](C)CCC1)C2=CC=C(C=C2)C=3C=CC(=O)NN3

-20°C

Ice Packs

Small Compound