Irdabisant hydrochloride - CAS 1005398-61-7

Irdabisant hydrochloride (CEP-26401) is a selective, orally active, and blood-brain barrier penetrating histamine H3 receptor (H3R) inverse agonist, demonstrating high affinity with K*i values of 7.2 nM and 2.0 nM for rat and human H3R, respectively. Exhibiting relatively low hERG current inhibitory activity with an IC*50 of 13.8 μM, this compound has shown to enhance cognition and promote wakefulness in rat social recognition models, suggesting potential applications in schizophrenia or cognitive impairment research.

Histamine Receptor, Others

Immunology/Inflammation, Neuroscience, GPCR/G Protein, Others

1005330

C18H24ClN3O2

349.86

Cl.C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1ccc(=O)[nH]n1

-20°C

Ice Packs

Small Compound