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IRE1α kinase-IN-1 - CAS 2328097-41-0

IRE1α kinase-IN-1 - CAS 2328097-41-0

MF-0019646-01

$120.88 USD
$120.88 USD
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Product Details

  • Bioactivity

    IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM, displaying 100-fold selectivity over the IRE1β isoform. It inhibits ER stress-induced IRE1α oligomerization and autophosphorylation, as well as IRE1α RNase activity (IC50=80 nM) .

  • Target

    IRE1

  • Related Pathways

    Cell Cycle/Checkpoint

  • CAS Number

    2328056

  • Purity

    0.997

  • Molecular Formula

    C26H26ClFN8

  • Molecular Weight

    504.99

  • SMILES

    CN1CCC(CNc2cc(Cl)nn3c(cnc23)-c2cc3nc(Nc4ccccc4)[nH]c3cc2F)CC1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound