IRF1-IN-2 - CAS 708245-32-3

IRF1-IN-2 is a small molecule inhibitor of interferon regulatory factor 1 (IRF1) that functions by reducing the binding affinity of IRF1 for the caspase-1 (CASP1) gene promoter. this inhibition subsequently suppresses critical cell death signaling pathways, such as pyroptosis, and provides robust protection against ionizing radiation-induced skin inflammatory damage in preclinical models.

Pyroptosis, Caspase, PARP, Interleukin, Glutathione Peroxidase, IFNAR

Chromatin/Epigenetic, Metabolism, Apoptosis, DNA Damage/DNA Repair, Proteases/Proteasome, Immunology/Inflammation

708210

0.9985

C18H20N2O4S

360.43

O=C(NC1=CC=C(C=C1)S(=O)(=O)N2CCCC2)C=3C=CC=CC3OC

-20°C

Ice Packs

Small Compound