Irigenin - CAS 548-76-5

Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the Extra Domain A domain. It can sensitize TRAIL-induced apoptosis by enhancing the expression of pro-apoptotic molecules in gastric cancer cells and has anti-cancer effects.

Integrin, Apoptosis, NF-κB

NF-κB, Cytoskeletal Signaling, Apoptosis

467

0.9985

C18H16O8

360.31

COc1cc(cc(O)c1OC)-c1coc2cc(O)c(OC)c(O)c2c1=O

-20°C

Ice Packs

Natural Product