IS4 - CAS 3067986-23-3

IS4 is a selective competitive antagonist of CXCR4, exhibiting an IC50 of 0.65 nM in THP-1 cells and 38.75 nM in Jurkat cells. It remains stable in serum and is non-cytotoxic. IS4 competes with CXCL12 for binding to CXCR4, thereby inhibiting CXCL12-induced intracellular Ca2+ release and cancer cell migration. This compound is applicable in research on the prevention of metastasis in conditions such as breast cancer, prostate cancer, and leukemia.

CXCR

GPCR/G Protein, Immunology/Inflammation, Autophagy

3067986-23-3

C48H62N14O11S2

1075.22

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-20°C

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