(Iso) -Flavokawain A - CAS 3420-72-2

NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. 3. Flavokawain A (Flavokavain A) may exert anti-inflammatory responses by suppressing LPS-induced expression of pro-inflammatory mediators via blockage of NF-κB-AP-1-JNK/p38 MAPK signaling pathways in the murine macrophages.

COX, JNK, ERK, Cytochromes P450, Histone Methyltransferase, Apoptosis, p38 MAPK, Akt, Caspase, PI3K, Survivin, NO Synthase, IAP

Neuroscience, MAPK, Immunology/Inflammation, PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Chromatin/Epigenetic, Proteases/Proteasome, Apoptosis, Metabolism

3346

0.9972

C18H18O5

314.332

O=C(C=CC1=CC=C(OC)C=C1)C=2C(O)=CC(OC)=CC2OC

-20°C

Ice Packs

Natural Product