Isoangustone A - CAS 129280-34-8

Isoangustone A is a natural product that inhibits PI3K, MKK4, and MKK7 through ATP competition, suppresses the expression of G1 phase regulatory proteins, inhibits the phosphorylation of Akt, GSK-3β, and JNK1/2, and inhibits the proliferation of human melanoma cells and tumour growth in xenograft mouse models.

Apoptosis, Autophagy, JNK, MAPK, PI3K

Apoptosis, Autophagy, MAPK, PI3K/Akt/mTOR signaling

129238

0.9889

C25H26O6

422.47

O=C1C(=COC2=CC(O)=C(C(O)=C12)CC=C(C)C)C=3C=C(O)C(O)=C(C3)CC=C(C)C

-20°C

Ice Packs

Natural Product