Isoforretin A - CAS 2231757-68-7

Isoforretin A is a potent inhibitor of thioredoxin-1 (Trx1) with significant biological activity, inducing anti-tumor effects mediated by reactive oxygen species (ROS) . The compound inhibits Trx1 activity by covalently binding to the activation site residues Cys32/Cys35, which triggers ROS accumulation, leading to DNA damage and apoptosis (Apoptosis) in cancer cells. Additionally, Isoforretin A has demonstrated the ability to suppress the growth of HepG2 tumors in a mouse hepatic cell carcinoma xenograft model.

Reactive Oxygen Species, Apoptosis

NF-κB, Metabolism, Apoptosis, Immunology/Inflammation

2231757-68-7

C28H38O10

534.6

C[C@]12[C@]3([C@]4(C[C@@]([C@@H](OC(C)=O)[C@@H]3OC(C)=O)(C(=C)C4=O)[H])C[C@@H](O)[C@@]1(C(C)(C)[C@@H](OC(C)=O)[C@@H](OC(C)=O)C2)[H])[H]

-20°C

Ice Packs

Small Compound