Isofraxidin - CAS 486-21-5

1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the protective effect of Isofraxidin seems to result from the inhibition of COX-2 protein expression in the lung, which regulates the production of PGE2. 3. Isofraxidin possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF-α and the phosphorylation of p38 and ERK1/2.

TLR, COX, MMP, ERK, p38 MAPK

Immunology/Inflammation, Proteases/Proteasome, MAPK, Neuroscience

460

0.997

C11H10O5

222.19

COc1cc2ccc(=O)oc2c(OC)c1O

-20°C

Ice Packs

Natural Product