Isopropyl ferulate - CAS 59831-94-6

Isopropyl ferulate is a bioactive compound from Rhizoma et Radix Notopterygii (Qianghuo) that exerts strong cytotoxic effects against PANC-1 human pancreatic cancer cells with a PC50 of 17.5 μg/mL, mechanistic analysis of Isopropyl ferulate via network pharmacology implicates Isopropyl ferulate regulate PI3K/Akt/mTOR, ErbB, and IL-17 pathways. Further validated in IMQ-induced and LPS-stimulated model systems, confirmed its significant modulation of PI3K/Akt/mTOR signaling, supporting the relevance of Isopropyl ferulate in cancer therapeutics.

AMPK, mTOR, EGFR, Akt, IL Receptor

Tyrosine Kinase/Adaptors, Cytoskeletal Signaling, Chromatin/Epigenetic, PI3K/Akt/mTOR signaling, Immunology/Inflammation, Angiogenesis, JAK/STAT signaling

59731

0.9991

C13H16O4

236.26

O=C(OC(C)C)C=CC1=CC=C(O)C(OC)=C1

-20°C

Ice Packs

Natural Product