Isoproterenol-d7 HCl - CAS 2517584-04-0

Isoproterenol-d7 is intended for use as an internal standard for the quantification of isoproterenol by GC- or LC-MS. Isoproterenol is an agonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 224 and 458 nM, respectively) . It is selective for β1- and β2-ARs over β3-ARs (Ki = 1,570 nM) . Isoproterenol inhibits contractions in isolated field-stimulated rat vas deferens (EC50 = 45.6 nM) . In vivo, isoproterenol (0.33 mg/kg) decreases blood pressure and increases water intake in nephrectomized rats. It reduces blood pressure and increases heart rate in renal hypertensive rabbits. Isoproterenol inhibits histamine-induced bronchospasms in anesthetized dogs. Formulations containing isoproterenol have been used in the treatment of bradydysrhythmias and to improve breathing during anesthesia.

Endogenous Metabolite, Adrenergic Receptor

Neuroscience, GPCR/G Protein, Metabolism

2517584-04-0

C11H18ClNO3

254.76

C(CNC(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])(O)C1=CC(O)=C(O)C=C1.Cl

-20°C

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