Isorhamnetin - CAS 480-19-3

Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LDL via inhibition of lectin-like ox-LDL receptor-1 upregulation, interference of ox-LDL-mediated intracellular signaling pathway (p38MAPK activation, NF-kappaB nuclear translocation, eNOS expression) and the antioxidant activity of isorhamnetin. Isorhamnetin prevents endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II. Isorhamnetin appears to be a potent drug against esophageal cancer due to it's in vitro potential to not only inhibit proliferation but also induce apoptosis of Eca-109 cells.

Endogenous Metabolite, PI3K, MEK

Metabolism, PI3K/Akt/mTOR signaling, MAPK

480-19-3

>99.99%

C16H12O7

316.26

COc1cc(ccc1O)-c1oc2cc(O)cc(O)c2c(=O)c1O

-20°C

Ice Packs

Natural Product