Isosilybin A - CAS 142796-21-2

Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC50=12.1-44.9μM) of tyrosinase. Isosilybin A shows anti-angiogenic efficacy, it has anti-prostate cancer (PCA) activity that is mediated via cell cycle arrest and apoptosis induction.

NF-κB, Apoptosis, p38 MAPK, Androgen Receptor, ABC Transporter, ERK, PPAR, Tyrosinase

NF-κB, Endocrinology/Hormones, DNA Damage/DNA Repair, Membrane transporter/Ion channel, MAPK, Apoptosis, Metabolism, Proteases/Proteasome

142773

0.9988

C25H22O10

482.44

COc1cc(ccc1O)[C@H]1Oc2ccc(cc2O[C@@H]1CO)[C@H]1Oc2cc(O)cc(O)c2C(=O)[C@@H]1O

-20°C

Ice Packs

Natural Product