Itacnosertib - CAS 1628870-27-8

Itacnosertib (TP-0184) is an orally available ACRV1 (ALK-2), FLT3 and JAK2 inhibitor that inhibits the growth of tumor cells overexpressing ALK-2, overcomes FLT3 inhibitor resistance and synergistically inhibits AML growth with venetoclax, and possesses potential antitumor and antileukemic activity.

FLT, Akt, mTOR, JAK, STAT, PI3K, ALK, TGF-beta/Smad

JAK/STAT signaling, Stem Cells, PI3K/Akt/mTOR signaling, Angiogenesis, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, Cytoskeletal Signaling

1628835

0.9938

C26H28N8O

468.55

N=1C=CC(=NC1NC2=CC=C(C(OC)=C2)N3CCN(C)CC3)NC=4C=CC=NC4C5=NC=CC=C5

-20°C

Ice Packs

Small Compound