(+) -ITD-1 - CAS 1409968-46-2

(+) -ITD-1 is an inhibitor of TGF-β, effectively inhibiting TGF-β2 with an IC50 of 0.46 μM. It promotes the degradation of the TGF-β type II receptor (TGFBR2) and the differentiation of cardiomyocytes. Additionally, it suppresses the formation of the mesoderm during the early differentiation of mouse embryonic stem cells (mESCs) .

TGF-beta/Smad

Stem Cells

1409920

C27H29NO3

415.52

C(OCC)(=O)C=1[C@@H](C2=C(NC1C)CC(C)(C)CC2=O)C3=CC=C(C=C3)C4=CC=CC=C4

-20°C

Ice Packs

Small Compound