ITF5924 - CAS 2760854-72-4

ITF5924 (compound 1), a potent HDAC6 inhibitor featuring a difluoromethyl-1,3,4-oxadiazole (DFMO) moiety, exhibits an IC 50 of 7.7 nM and surpasses 104-fold selectivity over other HDAC subtypes. As a slow-binding substrate analog of HDAC6, ITF5924 undergoes an enzyme-catalyzed ring opening reaction, resulting in the formation of a stable, long-lasting enzyme-inhibitor complex [1].

HDAC

Chromatin/Epigenetic, DNA Damage/DNA Repair

2760854-72-4

C21H18F2N8O

436.42

C(N1C=C(N=N1)C2=CC=C(NC=3NCCN3)C=C2)C4=CC=C(C=C4)C=5OC(C(F)F)=NN5

-20°C

Ice Packs

Small Compound