ITK-IN-6 - CAS 2616666-32-9

ITK-IN-6 is a potent and selective ITK inhibitor (Kd = 387 nM) . It binds directly to the ITK kinase domain. This compound prevents the release of pro-inflammatory cytokines and the activation and differentiation of Th2 and Th17 cells. ITK-IN-6 improves asthma progression by reducing inflammatory cell infiltration, mucus production, and IgE generation. It significantly inhibits airway inflammation and is used in asthma research.

Tyrosine Kinases

Tyrosine Kinase/Adaptors

2616625

C20H16Cl2N2O4S

451.32

O=C(NC1=CC=C(O)C(=C1)NS(=O)(=O)C)C2=CC=C(C=C2)C=3C=CC=C(Cl)C3Cl

-20°C

Ice Packs

Small Compound