ITK inhibitor 6 - CAS 2404604-06-2

ITK inhibitor 6 is a selective and potent ITK inhibitor that acts on ITK (IC50: 4 nM), BTK (IC50: 133 nM), JAK3 (IC50: 320 nM), EGFR (IC50: 2360 nM), LCK (IC50: 155 nM) . ITK inhibitor 6 inhibited the phosphorylation of PLCγ1 and ERK1/2 and showed anti-proliferative effect.

Others, Tyrosine Kinases

Others, Tyrosine Kinase/Adaptors

2404604-06-2

C28H24F2N4O2

486.51

O(CCNC(C=C)=O)C1=C2C=C(NC2=CC(CC3=CC=CC=C3)=C1)C=4C=5C(NN4)=CC(C(F)F)=CC5

-20°C

Ice Packs

Small Compound