Ivabradine hydrochloride - CAS 148849-67-6

Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 μM) . Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker, with negative chronotropic activity. Upon administration, ivabradine selectively binds to the intracellular portion of the HCN channel pore and blocks HCN channels in the pacemaker cells within the sinoatrial (SA) node. This inhibits the If (funny) pacemaker ion current, prevents the inward flow and intracellular accumulation of positively charged ions, reduces pacemaker activity and slows diastolic depolarization.

HCN Channel, Adrenergic Receptor

Neuroscience, GPCR/G Protein, Membrane transporter/Ion channel

148776

0.9973

C27H37ClN2O5

505.05

N1(C(=O)Cc2c(CC1)cc(c(c2)OC)OC)CCCN(C)C[C@@H]1c2c(cc(c(c2)OC)OC)C1.Cl

-20°C

Ice Packs

Small Compound