IWP-051 - CAS 1354041-91-0

IWP-051 is a potent, orally active sGC stimulator (EC50 = 290nM) . IWP-051 showed >99% plasma protein binding, high metabolic stability, high permeability, and no efflux in a Caco-2 model of intestinal absorption. IWP-051 achieves good alignment of potency, stability, selectivity, and pharmacodynamic effects while maintaining favorable pharmacokinetic properties with once-daily dosing potential in humans.

Others, Guanylate cyclase

Others, GPCR/G Protein

1353950

C17H11F2N5O2

355.3

C(N1C(=CC(=N1)C=2NC(=O)C(F)=CN2)C=3C=CON3)C4=C(F)C=CC=C4

-20°C

Ice Packs

Small Compound