J22352 - CAS 2252395-44-9

J22352, a PROTAC (proteolysis-targeting chimeras) -like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects in glioblastoma by promoting HDAC6 degradation. It does so by inhibiting autophagy and stimulating the antitumor immune response, further restoring host antitumor activity through the reduction of PD-L1's immunosuppressive activity.

Caspase, HDAC

DNA Damage/DNA Repair, Proteases/Proteasome, Apoptosis, Chromatin/Epigenetic

2252342

C24H21N3O4

415.44

ONC(=O)c1ccc(Cn2c3ccccc3c(=O)n(CCc3ccccc3)c2=O)cc1

-20°C

Ice Packs

Small Compound