JAB-2485 - CAS 2899209-55-1

JAB-2485 is a highly potent and selective inhibitor of Aurora kinase A (AURKA), boasting an IC 50 of 0.33 nM, and demonstrates approximately 1700-fold selectivity for AURKA over AURKB. It induces cell cycle arrest and apoptosis, making it a valuable compound for cancer research [1].

Aurora Kinase, Apoptosis

Cell Cycle/Checkpoint, Apoptosis, Chromatin/Epigenetic

2899209-55-1

C25H28ClF2N5O2

503.97

C([C@]1(C(O)=O)C[C@@H](C)N(CC2=C(F)C(Cl)=CC=C2)CC1)C=3N=C(NC=4NN=C(C)C4)C(F)=C(C)C3

-20°C

Ice Packs

Small Compound