JAK-IN-39 - CAS 2250013-34-2

JAK-IN-39 (compound 11) is a JAK inhibitor with IC50 values of 0.05 nM for JAK1, 1.18 nM for JAK2, and 0.03 nM for JAK3. It reduces cell viability in TF-1 cells and inhibits the production of TNFα and INFγ in lymphocytes in vitro.

JAK, TNF

Chromatin/Epigenetic, Apoptosis, Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Stem Cells

2249977

C25H26N10O2

498.54

N(C=1N2C(=CC(=N2)C=3N=C(OC)C=CC3)N=CC1C(N)=O)[C@H]4C(C)(C)CN(CC4)C5=CC=C(C#N)N=N5

-20°C

Ice Packs

Small Compound