JAK1/2-IN-1 - CAS 3023876-01-6

JAK1/2-IN-1 is a potent inhibitor of JAK1 and JAK2, with IC50 values of 0.4 nM and 8.1 nM, respectively. Additionally, JAK1/2-IN-1 inhibits IL-4 and IL-13, with IC50 values of 136.5 nM and 19.1 nM, respectively (WO2023244775A1; Example 33a) .

JAK, Interleukin

Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, JAK/STAT signaling, Stem Cells, Angiogenesis, Immunology/Inflammation

3023876-01-6

C19H19BF3N5O3

433.19

C(F)(F)(F)C1=C2C(=CC(NC=3N=C(N[C@@H]4[C@@H](C#N)CCOC4)C(C)=CN3)=C1)COB2O

-20°C

Ice Packs

Small Compound