JAK1-IN-17 - CAS 1315490-71-1

JAK1-IN-17 (Compound 31) is a highly selective JAK1 inhibitor with a Ki of 1.9 nM. It exhibits low whole blood migration, allowing it to maintain effective pharmacological activity in whole blood. JAK1-IN-17 is also a nitrile-containing compound that provides stable but weak reversible inhibition of CYP3A4 using a midazolam probe (IC50= 7.9 μM) . This compound is applicable in cancer research.

JAK

Stem Cells, JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic

1315418

C17H19N5O

309.37

[C@H](C)(O)C=1N(C2=C3C(NC=C2N1)=NC=C3)[C@@H]4CC[C@@H](C#N)CC4

-20°C

Ice Packs

Small Compound