JAK1-IN-18 - CAS 2459377-98-9

JAK1-IN-18 (Example 2) is a selective JAK1 inhibitor with an IC50 value of 0.15 nM, demonstrating significantly greater inhibitory potency for JAK1 compared to JAK2 and JAK3. It significantly reduces inflammation in ulcerative colitis (UC) mouse models induced by DSS and Crohn's disease (CD) rat models induced by DNBS. JAK1-IN-18 is applicable for research into autoimmune diseases (such as inflammatory bowel disease), viral infections (such as hepatitis B virus infection), and cancers (such as hematologic malignancies) .

JAK

Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Chromatin/Epigenetic, Stem Cells

2459270

C16H20F2N6O2

366.37

N(C1=C2C(=NC=C1C(N)=O)NC=C2)N3C[C@@H](C(NCC(F)F)=O)CCC3

-20°C

Ice Packs

Small Compound