JAK1-IN-4 - CAS 2091134-35-7

JAK1-IN-4 is a selective JAK1 inhibitor (IC50s: 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively) . JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM) .

JAK

Stem Cells, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis

2091092

C26H32FN9O2

521.59

N(C([C@@H](C)N1C[C@@H](C)N(C)CC1)=O)C2=C3C(C(=CN3)C4=NC(NC=5C(OC)=NN(C)C5)=NC=C4F)=CC=C2

-20°C

Ice Packs

Small Compound