JAK2-IN-7 - CAS 2593402-36-7

JAK2-IN-7, a selective inhibitor targeting Janus Kinase 2 (JAK2), exhibits inhibitory concentrations (IC50) of 3 nM for JAK2, 11.7 nM for SET-2 cells, and 41 nM for Ba/F3 V617F cells, indicative of its potency and selectivity. This compound demonstrates more than 14-fold selectivity against JAK1, JAK3, and FLT3, underlining its specificity. JAK2-IN-7 effectively induces cell cycle arrest at the G0/G1 phase and promotes apoptosis in tumor cells, manifesting significant antitumor activities [1].

JAK, FLT, Apoptosis

Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, Stem Cells, JAK/STAT signaling, Angiogenesis, Apoptosis

2593359

0.9954

C26H33N7O

459.59

C(/C=C/CN(C)C)(=O)N1CC=2C(=CC(NC=3N=C(C(C)=CN3)C4=CN(C(C)C)N=C4)=CC2)CC1

-20°C

Ice Packs

Small Compound