JAK3 covalent inhibitor-1 - CAS 2300106-50-5

JAK3 Covalent Inhibitor-1 is a compound characterized by its potent and selective inhibition of Janus kinase 3 (JAK3), possessing an IC50 of 11 nM and demonstrating a 246-fold selectivity compared to other JAKs.

JAK

Angiogenesis, Stem Cells, JAK/STAT signaling, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic

2300051

C22H17FN6O2S

448.47

N(C#N)[C@@H]1C=2C([C@H](NS(=O)(=O)C3=CC(F)=CC=C3)C1)=CC=C(C2)C4=C5C(=NC=N4)NC=C5

-20°C

Ice Packs

Small Compound