JAK3-IN-11 - CAS 2412734-00-8

JAK3-IN-11 (Compound 12) exhibits potent, noncytotoxic, irreversible, orally active JAK3 inhibitory activity (IC50 = 1.7 nM) with an excellent selectivity profile (>588-fold compared to other JAK isoforms), covalently binds to the ATP-binding pocket in JAK3. JAK3-IN-11 strongly inhibits JAK3-dependent signaling and T-cell proliferation which is a promising tool for studying autoimmune diseases [1].

JAK, Others

Chromatin/Epigenetic, Stem Cells, Tyrosine Kinase/Adaptors, Others, Angiogenesis, JAK/STAT signaling

2412734-00-8

C23H23N5O2

401.46

N(C=1N=C(C=CN1)C2=CC=C(NC(C=C)=O)C=C2)C3=CC=C(C=C3)N4CCOCC4

-20°C

Ice Packs

Small Compound