Jatrorrhizine hydroxide - CAS 483-43-2

Jatrorrhizine hydroxide is an alkaloid extracted from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial, and antioxidant activities. Jatrorrhizine hydroxide is a potent and orally active acetylcholinesterase inhibitor (IC50 = 872 nM) with over 115-fold selectivity over BuChE. Jatrorrhizine hydroxide reduces serotonin and norepinephrine uptake by blocking dopamine uptake-2 transporters.

Cholinesterase (ChE), 5-HT Receptor, Antibacterial

Neuroscience, Microbiology/Virology, GPCR/G Protein

438

0.9999

C20H21NO5

355.38

[OH-].OC=1C=C2C(=CC1OC)C=3C=C4C=CC(OC)=C(OC)C4=C[N+]3CC2

-20°C

Ice Packs

Natural Product